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Elliasu Y. Salifu, Mbuso A. Faya, James Abugri and Pritika Ramharack
Cancer remains a major challenge in the field of medicine, necessitating innovative therapeutic strategies. Mitogen-activated protein kinase (MAPK) signaling pathways, particularly Extracellular Signal-Regulated Kinase 1 and 2 (ERK1/2), play pivotal role...
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Emilio Palomares, Laurent Billon and Aurelien Viterisi
Crystallinity has played a major role in organic solar cells (OSCs). In small molecule (SM) bulk-heterojunction (BHJ) OSCs, the crystallinity and crystalline packing of SM donors have been shown to have a dramatic impact on the formation of an optimum mi...
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Zhonghua Xia, Pavel Karpov, Grzegorz Popowicz, Michael Sattler and Igor V. Tetko
Small-molecule drug design aims to identify inhibitors that can specifically bind to a functionally important region on the target, i.e., an active site of an enzyme. Identification of potential binding pockets is typically based on static three-dimensio...
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Minze Zhu, Andrew K. Whittaker, Felicity Y. Han and Maree T. Smith
Biodegradable polymers have been used as carriers in drug delivery systems for more than four decades. Early work used crude natural materials for particle fabrication, whereas more recent work has utilized synthetic polymers. Applications include the ma...
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Longxian Li, Min Zhu, Huang Huang, Tianxi Liang, Huan Su and Baiyu Xue
In order to understand the mechanism of hydrogen interaction on the surface of a plutonium?gallium system, the adsorption and dissociation behaviors of hydrogen molecules on the surface of a plutonium?gallium system were studied using the first-principle...
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Konstantin A. Koshechkin, Georgiy S. Lebedev, Eduard N. Fartushnyi and Yuriy L. Orlov
Recent developments in Digital Medicine approaches concern pharmaceutical product optimization. Artificial Intelligence (AI) has multiple applications for pharmaceutical products? lifecycle, increasing development speed, quality of the products, and effi...
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Amina Yasin, Abdul Rehman Yasin, Muhammad Rizwan Azam, Ali Raza, Robina Nazir and Ridab Adlan Elamin Abdalla
The p53 pathway has been the focus of many researchers in the last few decades owing to its pivotal role as a frontline cancer suppressant protein. It plays a vital role in maintaining cell cycle checkpoints and cell apoptosis in response to a broken DNA...
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Zheng Han, Zhihui Li, Zhiyong Bai, Xuguo Li and Jiazhong Zhang
There has been a concern that the accurate numerical simulation of multi-body flow, which is caused by the multiple disintegrations of expired spacecraft re-entering into the near space, has a critical bottleneck impact on the falling area of the disinte...
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Shu Taira, Akari Ikeda, Shoko Kobayashi, Hitomi Shikano, Ryuzoh Ikeda, Yuko Maejima, Shoichiro Horita, Jun Yokoyama and Kenju Shimomura
We compared four derivatization reagents to analyze catecholamines and amino acids by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry. 2,4,6-Trimethylpyrylium tetrafluoroborate (TMPy), 2,4-diphenyl-pyranylium tetrafluoroborate (DPP-...
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Tatjana Trunzer, Timothy Stummvoll, Melanie Porzenheim, Paula Fraga-García and Sonja Berensmeier
The potential-controlled sorption of charged molecules using multi-walled carbon nanotubes as electrodes is an innovative step to economizing chromatographic processes. However, any process design requires understanding the basic operators, such as mater...
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