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Cristobal Aguilar-Gallardo and Ana Bonora-Centelles
Cell and gene therapies represent promising new treatment options for many diseases, but also face challenges for clinical translation and delivery. Hospital-based GMP facilities enable rapid bench-to-bedside development and patient access but require si...
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Anna Maria Sacco, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Stefano Palermi, Rocco Spera, Rossana Gnasso, Giorgio Zinno, Veronica Romano and Immacolata Belviso
Cardiac regeneration is a critical endeavor in the treatment of heart diseases, aimed at repairing and enhancing the structure and function of damaged myocardium. This review offers a comprehensive overview of current advancements and strategies in cardi...
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Kristina Vukovic Ðerfi, Tea Vasiljevic and Tanja Matijevic Glavan
Head and neck squamous cell carcinoma (HNSCC) is a very heterogeneous cancer with a poor overall response to therapy. One of the reasons for this therapy resistance could be cancer stem cells (CSCs), a small population of cancer cells with self-renewal a...
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Ruta Palep?iene, Martynas Maciulevicius, Paulius Ruzgys, Baltramiejus Jak?tys and Saulius ?atkauskas
Gene electrotransfer (GET) is recognized as a promising technique for the development of an efficient tool for gene therapy. Such a therapy would have applications in the treatment of a variety of genetic diseases, including cancer. However, despite its ...
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Tsvetelina Batsalova, Alexander Vasil?kov, Dzhemal Moten, Anastasiia Voronova, Ivanka Teneva, Alexander Naumkin and Balik Dzhambazov
Bimetallic nanoparticles (BMNPs) combine unique and synergistic properties of two metals, allowing new specific applications. In this study, bimetallic AuFe nanoparticles and their conjugates with methotrexate (MTX) were obtained with an environmentally ...
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Zita Szalai, Anikó Magyariné Berkó, Nikolett Bódi, Edit Hermesz, Ágnes Ferencz and Mária Bagyánszki
Diabetes mellitus is often associated with vascular complications in which hyperglycemia-induced oxidative stress may be the cause of the impaired vessels and circulating blood cells. The aim of this study was to follow the hyperglycemia-related metaboli...
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Michele Basilicata, Giulia Marrone, Manuela Di Lauro, Eleonora Sargentini, Vincenza Paolino, Redan Hassan, Giuseppe D?Amato, Patrizio Bollero and Annalisa Noce
Gaucher disease (GD) is a lysosomal storage pathological condition, characterized by a genetic autosomal recessive transmission. The GD cause is the mutation of GBA1 gene, located on the chromosome 1 (1q21), that induces the deficiency of the lysosomal e...
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Jenna Williamson, Todd Callaway, Emmanuel Rollin and Valerie Ryman
Mastitis is a costly disease in dairy cattle as a result of decreased milk production, discarded milk, and other economic drivers such as treatment costs. Although it can be costly, effective antibiotic therapy is useful to ensure the health and producti...
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Andrew Carter, Seth Racey and Stephany Veuger
Iron is a key metal involved in several biological processes such as DNA replication and repair, cellular proliferation and cell cycle regulation. Excess volumes of labile iron are toxic and can lead to the production of ROS (reactive oxygen species) via...
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Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano, Alessia Carocci and Maria Stefania Sinicropi
Arsenic intoxication represents a worldwide health problem and occurs mainly through drinking water. Arsenic, a metalloid and naturally occurring element, is one of the most abundant elements in the earth?s crust, whose toxicity depends on the reduction ...
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