4   Artículos

 
en línea
Hiroshi Yamazaki, Kana Horiuchi, Ryohji Takano, Taku Nagano, Makiko Shimizu, Masato Kitajima, Norie Murayama and Fumiaki Shono    
The present study defined a simplified physiologically based pharmacokinetic (PBPK) model for nicotine and its primary metabolite cotinine in humans, based on metabolic parameters determined in vitro using relevant liver microsomes, coefficients derived ... ver más

 
en línea
Taku Nagano, Makiko Shimizu, Kazuma Kiyotani, Tetsuya Kamataki, Ryohji Takano, Norie Murayama, Fumiaki Shono and Hiroshi Yamazaki    
Human biomonitoring of plasma and urinary levels of nicotine, cotinine, and 3'-hydroxycotinine was conducted after daily cigarette smoking in a population of 92 male Japanese smokers with a mean age of 37 years who had smoked an average of 23 cigarettes ... ver más

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