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Andrew Carter, Seth Racey and Stephany Veuger
Iron is a key metal involved in several biological processes such as DNA replication and repair, cellular proliferation and cell cycle regulation. Excess volumes of labile iron are toxic and can lead to the production of ROS (reactive oxygen species) via...
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Claudia Tapia-Larios, Ernesto García Mendoza, María Carmen Rubio-Armendáriz and Jesus Olivero-Verbel
Highly toxic microcystins (MCs) perform complex interactions with many proteins that induce cellular dysregulation, leading to the development of several diseases including cancer. There is significant diversity and chemical complexity among MC congeners...
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Jacopo Troisi, Angelo Colucci, Pierpaolo Cavallo, Sean Richards, Steven Symes, Annamaria Landolfi, Giovanni Scala, Francesco Maiorino, Alfonso Califano, Marco Fabiano, Gianmarco Silvestre, Federica Mastella, Alessandro Caputo, Antonio D?Antonio and Vincenzo Altieri
Here we describe a serum metabolomics signature of bladder cancer coupled with a robust ensemble machine learning algorithm able to effectively discriminate patients with and without bladder cancer. This signature, if further confirmed and validated on a...
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Miey Park, So-Hyeun Kim and Hae-Jeung Lee
Alzheimer?s disease (AD) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid plaques and hyperphosphorylated tau proteins in the brain. Cell signaling pathways such as PI3K/Akt are known to play an essential role in regulating ...
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Encarna Aguayo, Ascensión Martínez-Sánchez, Bárbara Fernández-Lobato and Fernando Alacid
L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health pot...
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Ivana Hyrslova, Gabriela Krausova, Jana Smolova, Barbora Stankova, Tomas Branyik, Hana Malinska, Martina Huttl, Antonin Kana, Ladislav Curda and Ivo Doskocil
The market for new functional foods and food supplements is rapidly evolving, with a current emphasis on using natural sources. Algae, probiotics, and colostrum are rich sources of nutrients and bioactive compounds with positive effects on human and anim...
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Hanen Mhamdi, Jérémie Bourdon, Abdelhalim Larhlimi and Mourad Elloumi
The integration of high-throughput data to build predictive computational models of cellular metabolism is a major challenge of systems biology. These models are needed to predict cellular responses to genetic and environmental perturbations. Typically, ...
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Alexandra Iulia Irimie, Cornelia Braicu, Roxana Cojocneanu, Lorand Magdo, Anca Onaciu, Cristina Ciocan, Nikolay Mehterov, Diana Dudea, Smaranda Buduru and Ioana Berindan-Neagoe
Smoking is a well-known behavior that has an important negative impact on human health, and is considered to be a significant factor related to the development and progression of head and neck squamous cell carcinomas (HNSCCs). Use of high-dimensional da...
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Robert Snyder
Excessive exposure to benzene has been known for more than a century to damage the bone marrow resulting in decreases in the numbers of circulating blood cells, and ultimately, aplastic anemia. Of more recent vintage has been the appreciation that an alt...
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