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Lei Cao, Won Han, Sang Gil Lee and Joong Ho Shin
Cell-culture-based drug tests are usually performed in an instantaneous delivery manner. However, in vivo pharmacokinetic studies have shown a steady increase in the concentration of bioactive compounds in the plasma following oral administration, with t...
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Yoko Sakai, Masanari Matsumura, Hideki Yamada, Atsushi Doi, Isao Saito, Takahiro Iwao and Tamihide Matsunaga
There is an increasing need to develop alternatives to animal modeling and testing for pre-clinical studies as researchers face major challenges, such as the study of dynamic systems in laboratory settings. Microphysiological system (MPS) technology has ...
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Encarna Aguayo, Ascensión Martínez-Sánchez, Bárbara Fernández-Lobato and Fernando Alacid
L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health pot...
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Sophia Ferng, Ching-Hua Ting, Chien-Ping Wu, Yung-Tsong Lu, Cheng-Kuang Hsu, Robin Yih-Yuan Chiou
Pág. 70 - 77
Compartment modelling has been successfully used in pharmacokinetics to describe the kinetics of drug distribution in body tissues. In this study, the technique is adopted to describe the dynamics of temperature response and energy exchange in a soy mash...
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Mohammed Zaghlool Al-Khayyat
Pág. 1 - 9
Introduction: Chorismate synthase catalyzes the final step in shikimate acid pathway involved in synthesis of aromatic compounds in bacteria. This enzyme can be a possible molecular target for design of antibiotics. Materials and Methods: Homology modeli...
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Sebastian Sailer, Giorgia Sebastiani, Vicente Andreu-Férnández and Oscar García-Algar
Maternal tobacco smoking during pregnancy remains a major public health issue. The neurotoxic properties of nicotine are associated with fetal neurodevelopmental disorders and perinatal morbimortality. Recent research has demonstrated the effects of nico...
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L. Gutierrez, L. Ocampo, C. Rosario, and H. Sumano
Pág. 2106 - 2115
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Deacqunita L. Harris, Darryl B. Hood and Aramandla Ramesh
The objective of this study was to evaluate how the vehicles of choice affect the pharmacokinetics of orally administered Fluoranthene [FLA] in rats. Fluoranthene is a member of the family of polycyclic aromatic hydrocarbon chemicals. Fluoranthene exposu...
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A.R. Schramme, C.R. Pinto, J.L. Davis, M.D. Whitacre and C.S. Whi
Pág. 517 - 518
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I-Chiu Chang, Hsin-Ginn Hwang, Won-Fu Hung and Yi-Cha
Pág. 296 - 303
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