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Jesus Vicente de Julián-Ortiz and Emili Besalú
The design of fungicides is a central topic in agricultural chemistry. In this manuscript, it is shown how the Superposition of Significant Interaction Rules (SSIR) method can serve the generation of new potentially active molecules. By using SSIR, it is...
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Esther Y. Akoto and Dirk E. Maier
This paper thoroughly reviews the mechanism of veterinary drug carryover in feed manufacturing facilities, factors resulting in varying concentrations of drug carryover in processing equipment, the impact of chemical and physical properties of drugs, and...
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Blessing Magocha, Mokgadi Molope, Martin Palamuleni and Munyaradzi Saruchera
An over-reliance on donor funding for HIV/AIDS healthcare services remains a concern in Africa. This study, therefore, explores the partnership between the Zimbabwean government and an international non-governmental organisation in delivering HIV/AIDS he...
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Subrat Kumar Bhattamisra, Priyanka Banerjee, Pratibha Gupta, Jayashree Mayuren, Susmita Patra and Mayuren Candasamy
Artificial intelligence (AI) is a branch of computer science that allows machines to work efficiently, can analyze complex data. The research focused on AI has increased tremendously, and its role in healthcare service and research is emerging at a great...
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Christos Koroulis, Evangelos Makris, Angelos Kolaitis, Panayiotis Tsanakas and Christos Pavlatos
The observation and analysis of RNA molecules have proved crucial for the understanding of various processes in nature. Scientists have mined knowledge and drawn conclusions using experimental methods for decades. Leveraging advanced computational method...
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Aleksandra Galarda and Joanna Goscianska
Migraine is now the sixth most common disease in the world and affects approximately 15% of the population. Non-steroidal anti-inflammatory drugs, including ketoprofen, diclofenac sodium, and ibuprofen, are often used during migraine attacks. Unfortunate...
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Andrew Carter, Seth Racey and Stephany Veuger
Iron is a key metal involved in several biological processes such as DNA replication and repair, cellular proliferation and cell cycle regulation. Excess volumes of labile iron are toxic and can lead to the production of ROS (reactive oxygen species) via...
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Zhonghua Xia, Pavel Karpov, Grzegorz Popowicz, Michael Sattler and Igor V. Tetko
Small-molecule drug design aims to identify inhibitors that can specifically bind to a functionally important region on the target, i.e., an active site of an enzyme. Identification of potential binding pockets is typically based on static three-dimensio...
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Homa Maleki, Bahareh Azimi, Saeed Ismaeilimoghadam and Serena Danti
Poly(lactic acid)(PLA) is an aliphatic polyester that can be derived from natural and renewable resources. Owing to favorable features, such as biocompatibility, biodegradability, good thermal and mechanical performance, and processability, PLA has been ...
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Yuko Terada, Kenjiro Tanaka, Minami Matsuyama, Masaya Fujitani, Masatoshi Shibuya, Yoshihiko Yamamoto, Ryuji Kato and Keisuke Ito
Because transient receptor potential ankyrin 1 (TRPA1) is involved in various physiological functions, TRPA1-targeting drugs have been energetically developed. Although TRPA1 is considered a multimodal receptor, the structural diversity of TRPA1 agonists...
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