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Marianna Capecci, Nicolò Baldini, Francesca Campignoli, Lorenzo Pasquale Lombardo, Elisa Andrenelli and Maria Gabriella Ceravolo
The COVID-19 pandemic has been a stress test for the population, especially for people with chronic disorders such as Parkinson?s disease (PD). In addition to public health restrictions that contrast with PD management recommendations, there were deep ch...
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Harold Dadomo, Davide Ponzi, Silvia Paterlini, Stefano Parmigiani and Paola Palanza
Age-dependent cognitive decline is associated with a downregulation of the cyclic nucleotide cascade. Through their regulation of the cGMP pathway, phosphodiesterase 5 inhibitors have been proven to enhance episodic memory in rodents and mice and have be...
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Simone Brogi, Ilaria Guarino, Lorenzo Flori, Hajar Sirous and Vincenzo Calderone
In this study, we applied a computer-based protocol to identify novel antioxidant agents that can reduce oxidative stress (OxS), which is one of the main hallmarks of several disorders, including cancer, cardiovascular disease, and neurodegenerative diso...
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Diletta Piatti, Riccardo Marconi, Giovanni Caprioli, Simone Angeloni, Massimo Ricciutelli, Gokhan Zengin, Filippo Maggi, Luca Pagni and Gianni Sagratini
This study assessed the impact of full and late flowering stages on the polyphenols and enzyme inhibitory properties of Hypericum perforatum from Poland. Recognizing the significance of phenolic compounds in disease prevention and melatonin?s emerging pr...
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Alberto J. Nuñez-Selles, Lauro Nuevas-Paz and Gregorio Martínez-Sánchez
Metal?mangiferin complexes as antioxidant and protecting agents against protein oxidative damage in adjuvant therapies of pathologies of high morbidity and mortality: neurodegenerative diseases, cancer, diabetes, and cardiovascular disorders.
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Luciana Rigoli, Valerio Caruso, Concetta Aloi, Alessandro Salina, Mohamad Maghnie, Giuseppe d'Annunzio, Olga Lamacchia, Giuseppina Salzano, Fortunato Lombardo and Giuseppe Picca
Wolfram syndrome 1, a rare autosomal recessive neurodegenerative disease, is caused by mutations in the WFS1 gene. It is characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness (DIDMOAD), and other clinical manifestations such...
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Min Hye Kang, Yun-Jeong Ji, Yu Mi Han, Gwi Yeong Jang, Dong Hwi Kim, Jeong Hoon Lee, Geum-Soog Kim, Su Ji Choi and Hyung Don Kim
The overproduction of reactive oxygen species (ROS) can cause oxidative stress to biomolecules such as nucleic acids, proteins, and lipids, leading to neurodegenerative disorders. Sasa borealis (SB) has antioxidant, anti-inflammatory, antidiabetic, and a...
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M. El Arayshi, C. M. Verrelli, G. Saggio, M. Iosa, A. E. Gentile, L. Chessa, M. Ruggieri and A. Polizzi
Background. It has been shown in the very recent literature that human walking generates rhythmic motor patterns with hidden time harmonic structures that are represented (at the subject?s comfortable speed) by the occurrence of the golden ratio as the t...
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Haya I. Aljohar, Abdulmajeed A. Alghamdi, Nasr Y. Khalil, Hany W. Darwish, Rashad Al-Salahi and Ibrahim A. Darwish
The Food and Drug Administration (FDA) has approved duvelisib (DUV) for managing follicular lymphoma, small lymphocytic lymphoma, and relapsed or refractory chronic lymphocytic leukemia. Seliciclib (SEL) is a candidate drug for these cancers, neurodegene...
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Miey Park, So-Hyeun Kim and Hae-Jeung Lee
Alzheimer?s disease (AD) is a neurodegenerative disorder characterized by the accumulation of ß-amyloid plaques and hyperphosphorylated tau proteins in the brain. Cell signaling pathways such as PI3K/Akt are known to play an essential role in regulating ...
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