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Dmitry Grebennikov, Rostislav Savinkov, Ekaterina Zelenova, Gennady Lobov and Gennady Bocharov
Animal models of diseases, particularly mice, are considered to be the cornerstone for translational research in immunology. The aim of the present study is to model the geometry and analyze the network structure of the murine lymphatic system (LS). The ...
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Daniele Pergolini, Andrea Botticelli, Roberta Fascetti, Federica Rocchetti, Alessio Cirillo, Gianluca Tenore, Gaspare Palaia, Antonella Polimeni and Umberto Romeo
Introduction: Immune Checkpoint Inhibitor (ICI) drugs have led to a revolution in the treatment of different forms of cancer, shifting the target of action from cancer cells to the patient?s immune system, enhancing their responses against the tumor itse...
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Deniz Can Guven, Taha Koray Sahin, Alessandro Rizzo, Angela Dalia Ricci, Sercan Aksoy and Kazim Sahin
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy and reshaped medical oncology practice over the past decade. However, despite unprecedented and durable clinical responses, most patients eventually fail to respond to ICI therapy due...
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Jessica Imbrescia, Giulia Volpi, Silvia Lucchini, Cristian Toraci, Giorgio Facheris, Salvatore La Mattina, Navdeep Singh, Filippo Vaccher, Andrea Guerini, Michela Buglione di Monale e Bastia, Alessio Bruni and Paolo Borghetti
Background: The standard treatment for locally advanced non-small cell lung cancer (LA-NSCLC) is represented by concomitant chemo-radiotherapy followed by consolidation with durvalumab that ensures a 5-year survival of 46%. However, the risk of radiother...
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OPhir Nave and Moriah Sigron
Skin cancer treatment is a combination of BRAF and MEK kinase inhibitors administered as tablets, along with immunotherapy treatment (treatment into the vein) with a group of drugs that inhibit the activity of the immune barrier proteins PD-1 and PDL1. H...
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Juan Carlos Chimal-Eguia, Erandi Castillo-Montiel, Julio Cesar Rangel-Reyes and Ricardo Teodoro Paez-Hernández
Nowadays, immunotherapy has become an important alternative to fight cancer. One way in which biologists and medics use immunotherapy is by injecting antigen-incubated Dendritic Cells (DCs) into mice to stimulate an immune response. The DCs optimal quant...
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Takahiro Yamasaki, Issei Saeki, Yurika Kotoh-Yamauchi, Ryo Sasaki, Norikazu Tanabe, Takashi Oono, Takashi Matsuda, Takuro Hisanaga, Toshihiko Matsumoto, Isao Hidaka, Tsuyoshi Ishikawa, Taro Takami, Yutaka Suehiro and Isao Sakaida
Recent success of systemic therapeutic agents, including combination immunotherapy, could promote a change in the treatment strategy in patients with advanced hepatocellular carcinoma (HCC). Although hepatic arterial infusion chemotherapy (HAIC) is a tre...
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Anis Ahmad, Tulasigeri M. Totiger, Ana Paula Benaduce, Brian Marples and Ivaylo Bodganov Mihaylov
Triple-negative breast cancer (TNBC), which is a type of invasive breast cancer, is characterized by severe disease progression, poor prognosis, high recurrence rate, and short survival. We sought to gain new insight into TNBC by applying computed tomogr...
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Human papillomavirus (HPV) infection is related to frequent cases of cervical cancer and genital condyloma in humans. Up to now, numerous methods have come into existence for the prevention and treatment of this disease. In this context, this paper aims ...
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Khalid Kassara
Pág. 1114 - 1125
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