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ARTÍCULO
TITULO

Association between Serum Selenium Concentrations and Levels of Proinflammatory and Profibrotic Cytokines?Interleukin-6 and Growth Differentiation Factor-15, in Patients with Alcoholic Liver Cirrhosis

Andrzej Prystupa    
Pawel Kicinski    
Dorota Luchowska-Kocot    
Anna Blazewicz    
Jaroslaw Niedzialek    
Grzegorz Mizerski    
Mariusz Jojczuk    
Andrzej Ochal    
Jaroslaw J. Sak and Wojciech Zaluska    

Resumen

According to some authors, serum selenium levels are strongly associated with the severity of liver diseases, including liver cirrhosis. The aim of this study was to determine the relationship between the concentration of selenium and pro-inflammatory and profibrotic cytokines?interleukin-6 (IL-6) and growth differentiation factor 15 (GDF-15) in patients with alcoholic liver cirrhosis. The parameters studied were determined in the serum of 99 patients with alcoholic liver cirrhosis divided based on the severity of disease according to the Child-Turcotte-Pugh criteria. In patients with liver cirrhosis, the serum selenium concentration was statistically lower, whereas serum IL-6 and GDF-15 concentrations were higher than those in the control group. Moreover, the concentration of selenium negatively correlated with the levels of GDF-15 and IL-6. The above results may indicate a role of selenium deficiency in the pathogenesis and progression of alcoholic liver disease.

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