Inicio  /  Applied Sciences  /  Vol: 13 Par: 8 (2023)  /  Artículo
ARTÍCULO
TITULO

Scale-up and Economic Assessment of Biofunctional Particles Synthesis for Bilirubin Removal

María del Prado Garrido    
Juan Francisco Rodriguez    
Maria Jesús Ramos    
Manuel Carmona    
Francisco Javier Redondo Calvo and Ana Maria Borreguero    

Resumen

The scale-up and the economic feasibility of the synthesis of St-MMA-GMA-PEGMA particles biofunctionalized with HSA were studied. First, the geometrical similarity of laboratory and pilot plant reactors was checked to develop the scale up of the process according to a criterion of partial similarity. The selected criterion was constant Re number. Then, a reaction in the pilot plant scale was carried out, confirming the suitability of the scale-up criterion, since particles with similar characteristics (same particle size with a deviation of just 6%) and functional groups were obtained. Finally, the design of an industrial plant able to produce 581 Tm/year of HSA functionalized St-MMA-GMA-PEGMA particles was addressed. The economic feasibility of this plant was confirmed by a value of internal rate of return (IRR) of 14.8% and a net present value (NPV) of 5452 M?, with a payback time between six and seven years, for the price of a cartridge 25% lower than that from the current treatments for bilirubin removal from patients with liver failure.

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