Inicio  /  Applied Sciences  /  Vol: 11 Par: 14 (2021)  /  Artículo
ARTÍCULO
TITULO

Effects of Workers Exposure to Nanoparticles Studied by NMR Metabolomics

?tepán Horník    
Lenka Michálková    
Jan Sýkora    
Vladimír ?dímal    
?tepánka Vlcková    
?tepánka Dvorácková and Daniela Pelclová    

Resumen

In this study, the effects of occupational exposure to nanoparticles (NPs) were studied by NMR metabolomics. Exhaled breath condensate (EBC) and blood plasma samples were obtained from a research nanoparticles-processing unit at a national research university. The samples were taken from three groups of subjects: samples from workers exposed to nanoparticles collected before and after shift, and from controls not exposed to NPs. Altogether, 60 1H NMR spectra of exhaled breath condensate (EBC) samples and 60 1H NMR spectra of blood plasma samples were analysed, 20 in each group. The metabolites identified together with binning data were subjected to multivariate statistical analysis, which provided clear discrimination of the groups studied. Statistically significant metabolites responsible for group separation served as a foundation for analysis of impaired metabolic pathways. It was found that the acute effect of NPs exposure is mainly reflected in the pathways related to the production of antioxidants and other protective species, while the chronic effect is manifested mainly in the alteration of glutamine and glutamate metabolism, and the purine metabolism pathway.

 Artículos similares

       
 
Thanatorn Chuenyindee, Robimarl B. Torres, Yogi Tri Prasetyo, Reny Nadlifatin and Satria Fadil Persada    
The shoe industry has been continuously growing in recent years. The goal of this study was to identify factors affecting perceived shoe quality among shoe manufacturing workers. A sample of 350 shoe manufacturing workers participated in answering a surv... ver más

 
Farah Salwati Ibrahim, Muneera Esa, Ernawati Mustafa Kamal    
Malaysia has seen the third wave of infection since the start of the global COVID-19 pandemic, with approximately 103 construction sites involving over 14,667 workers reported from April 2020 to February 2021. This has led to limited progress in construc... ver más

 
Dominik Ziemke, Nico Kuehnel, Carlos Llorca, Rolf Moeckel, Kai Nagel     Pág. 497 - 526
Integrated land-use transport models are often accused of being too complex, too coarse or too slow. We tightly couple the microscopic land use model SILO (Simple Integrated Land Use Orchestrator) with the agent-based transport simulation model MATSim (M... ver más

 
Teresa Baptista, Marina Almeida-Silva, Dário Silva, Carlos Diogo and Nuno Canha    
Indoor Air Quality (IAQ) is a public and occupational health concern, as we are exposed to air pollutants daily given that we spend a great amount of our time in indoor environments. IAQ can be affected by numerous factors, from outdoor pollutants that g... ver más
Revista: Applied Sciences

 
Chun-Yip Hon and Naqiyah Motiwala    
Although biological monitoring is beneficial as it assesses all possible routes of exposure, urine sampling of healthcare workers exposed to hazardous drugs is currently not routine. Therefore, a scoping review was performed on this subject matter to und... ver más
Revista: Applied Sciences