Resumen
This study aimed to investigate the effect of combining an innovative bioceramic a-calcium sulfate hemihydrate (a-CSH, CaSO4·0.5H2O) bone graft and platelet-rich plasma (PRP) to accelerate bone healing and regeneration in a rabbit model. The bone graft material was implanted bilaterally on rabbit?s artificially maxillary sinus defects: the right maxillary sinus received a-CSH, while a-CSH combine with PRP (a-CSH/PRP) was grafted in left site. The quantity and quality of bone formation after implantation were analyzed radiographically and histologically at 1, 2, and 3 weeks. The micro-computed tomographic results indicated that the bone density of sinus implanted with a-CSH increased and defect volume decreased most after 2 weeks. In histological analysis, both hematoxylin and eosin and Masson trichrome staining of a-CSH/PRP displays better bone healing and regeneration progress than a-CSH after 2 weeks implantation. Therefore, the innovative a-CSH combined with PRP was revealed to be useful in accelerating bone healing and regeneration for the successful defect treatment.