Resumen
Extinction of species has been a recurrent phenomenon in the history of our planet, but it was generally outweighed in the course of quite a long geological time by the appearance of new species, except, especially, for the five geologically short times when the so-called ?Big Five? mass extinctions occurred. Could the current decline in biodiversity be considered as a signal of an ongoing, human-driven sixth mass extinction? This note briefly examines some issues related to: (i) The hypothesized current extinction rate and the magnitude of contemporary global biodiversity loss; (ii) the challenges of comparing them to the background extinction rate and the magnitude of the past Big Five mass extinction events; (iii) briefly considering the effects of the main anthropogenic stressors on ecosystems, including the risk of the emergence of pandemic diseases. A comparison between the Pleistocene fauna dynamics with the present defaunation process and the cascading effects of recent anthropogenic actions on ecosystem structure and functioning suggests that habitat degradation, ecosystem fragmentation, and alien species introduction are important stressors increasing the negative impact on biodiversity exerted by anthropogenic-driven climate changes and their connected effects. In addition, anthropogenic ecological stressors such as urbanization, landscapes, and wildlife trade, creating new opportunities for virus transmission by augmenting human contact with wild species, are among the main factors triggering pandemic diseases.