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Laura Mosca, Francesca Vitiello, Martina Pagano, Alessandra Coppola, Roberta Veglia Tranchese, Roberta Grillo, Giovanna Cacciapuoti and Marina Porcelli
Squamous cell carcinoma of the head and neck (HNSCC), which includes cancers of the oral cavity and larynx, is one of the most common and highly aggressive malignancies worldwide, despite significant efforts committed in recent decades in its detection, ...
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Ali Irfan, Sami Ullah, Ayesha Anum, Nazish Jabeen, Ameer Fawad Zahoor, Hafza Kanwal, Katarzyna Kotwica-Mojzych and Mariusz Mojzych
The 1,2,3-thiadiazole moiety occupies a significant and prominent position among privileged heterocyclic templates in the field of medicine, pharmacology and pharmaceutics due to its broad spectrum of biological activities. The 1,2,3-thiadiazole hybrid s...
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Ali Irfan, Sajjad Ahmad, Saddam Hussain, Fozia Batool, Haseeba Riaz, Rehman Zafar, Katarzyna Kotwica-Mojzych and Mariusz Mojzych
Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of...
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Alessandro de Sire, Antonio Ammendolia, Lorenzo Lippi, Giacomo Farì, Carlo Cisari and Marco Invernizzi
?Mixed pain? is a term recently introduced to define the overlapping of nociceptive, neuropathic and nociplastic pain. To date, it has been reported that pharmacological treatments might have a modest effectiveness on patients affected by mixed chronic p...
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Encarna Aguayo, Ascensión Martínez-Sánchez, Bárbara Fernández-Lobato and Fernando Alacid
L-Arginine (Arg) has been widely used due to its functional properties as a substrate for nitric oxide (NO) generation. However, L-citrulline (CIT), whose main natural source is watermelon, is a non-essential amino acid but which has important health pot...
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