Resumen
This paper is investigating various patterns of entrepreneurial relations and engagements that may help the shift to bio economy and the ways they can facilitate entrepreneurial understanding and access to markets and business opportunities in this field. It also investigate the role of universities and cluster in transfer of knowledge towards bio economy and possibilities of interaction making a case study on USH ProBusiness in Romania. Main conclusion of the paper is that participation of entrepreneurs, especially SME but also large companies in active Entrepreneurial Ecosystems (EE) plays an essential role in transposing bio economy from strategy to action but some regions may be well advanced and other lagging behind. High trust and large EE in terms of networking are better fit to accelerate the knowledge and innovation process and universities may play a major role in this direction, as important catalyst.