Resumen
Aim: The aim was to assess the effect of antimicrobial photodynamic therapy (a-PDT) on the oral health-related quality of life (OHRQoL) of denture stomatitis patients. Methods: Forty patients were randomly selected to participate. Candidal proliferation was confirmed by using a CHROMagar culture and Gram staining. The denture surface and palatal mucosa were sprayed with a methylene blue photosensitizer prior to the photobiomodulation application. Laser therapy was applied two times a week at 72 h intervals for a period of 8 weeks. The OHIP-EDENT questionnaire was used to analyze the improvement in the OHRQoL. A Wilcoxon test was used to perform the candidal colony-forming unit?s count and comparison. A t-test was applied to evaluate the OHRQoL responses. Results: The overall CFU/mL values were higher in the dentures of the patients compared to a palatal mucosa swab. For instance, the CFU count was reduced from 5.56 ± 2.15 (baseline) to 3.17 ± 2.77 CFU/mL on day 60 on the palates. Similarly, the a-PDT application on the intaglio surface of the denture showed a reduction from 38.83 ± 14.71 to 29.05 ± 15.52 CFU/mL. A significant difference (p < 0.05) was found in function improvement as well as a reduction in physical pain, psychological discomfort, physical disability, and social interaction among the participants after photobiomodulation treatment. Conclusions: The OHRQoL was significantly improved in the DS patients. The Candida albicans abundance was radically reduced after the a-PDT application.