Resumen
In the last decade, pretreatment has been considered the core stage in the design of biorefineries. Different schemes could be proposed depending on the design objective, either pretreatments for the feedstock fractionation or pretreatments to obtain a platform product. Nevertheless, many have been described as single-step pretreatments specific to a sub-stream, decreasing the integral valorization performance. This work demonstrates the possibility of sequential pretreatment schemes to maximize the fractionation of lignocellulosic biomass. Through different operational, technical, and economic assessment indicators, the best schemes that would help increase the overall process yields and, certainly, the economic viability are described. Therefore, a good pretreatment design will affect the upstream and downstream performance of the biorefineries.