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Claudia Tapia-Larios, Ernesto García Mendoza, María Carmen Rubio-Armendáriz and Jesus Olivero-Verbel
Highly toxic microcystins (MCs) perform complex interactions with many proteins that induce cellular dysregulation, leading to the development of several diseases including cancer. There is significant diversity and chemical complexity among MC congeners...
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Cosmin Trif, Dragos Paul Mihai, Anca Zanfirescu and George Mihai Nitulescu
The fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of anandamide, an endocannabinoid. Pharmacologically blocking this target can lead to anxiolytic effects; therefore, new inhibitors can improve therapy in this field. In o...
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Yuko Terada, Kenjiro Tanaka, Minami Matsuyama, Masaya Fujitani, Masatoshi Shibuya, Yoshihiko Yamamoto, Ryuji Kato and Keisuke Ito
Because transient receptor potential ankyrin 1 (TRPA1) is involved in various physiological functions, TRPA1-targeting drugs have been energetically developed. Although TRPA1 is considered a multimodal receptor, the structural diversity of TRPA1 agonists...
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Archana Lakshmanan, Balamuralikrishnan Balasubramanian, Viji Maluventhen, Arunkumar Malaisamy, Rathinasamy Baskaran, Wen-Chao Liu and Maruthupandian Arumugam
Fucoidan, a polymer derived from seaweed, poses a broad range of biological applications, and its potential medicinal benefits have been widely studied over the past decade. In this study, fucoidan was extracted from marine macroalga Sargassum ilicifoliu...
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Siripat Chaichit, Pathomwat Wongrattanakamon, Busaban Sirithunyalug, Piyarat Nimmanpipug and Supat Jiranusornkul
Osteoporosis is a complex bone disease indicating porous bone with low bone mass density and fragility. Cathepsin K, V-ATPase, and aVß3 integrin are exhibited as novel targets for osteoporosis treatment. Our preliminary study uses a state-of-the-art meth...
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