Acceso al sitio web del Consejo de Políticas de Infraestructura
REVISTA
Computation

   
Redirigiendo al acceso original de articulo en 21 segundos...
Inicio  /  Computation  /  Vol: 8 Par: 2 (2020)  /  Artículo
ARTÍCULO
TITULO

Computational View toward the Inhibition of SARS-CoV-2 Spike Glycoprotein and the 3CL Protease

Zhen Qiao    
Hongtao Zhang    
Hai-Feng Ji and Qian Chen    

Resumen

Since the outbreak of the 2019 novel coronavirus disease (COVID-19), the medical research community is vigorously seeking a treatment to control the infection and save the lives of severely infected patients. The main potential candidates for the control of viruses are virally targeted agents. In this short letter, we report our calculations on the inhibitors for the SARS-CoV-2 3CL protease and the spike protein for the potential treatment of COVID-19. The results show that the most potent inhibitors of the SARS-CoV-2 3CL protease include saquinavir, tadalafil, rivaroxaban, sildenafil, dasatinib, etc. Ergotamine, amphotericin b, and vancomycin are most promising to block the interaction of the SARS-CoV-2 S-protein with human ACE-2.

PÁGINAS
pp. 0 - 0

 Artículos similares

       
 
María Isabel Lamas Galdo, María Jesús Rodríguez Guerreiro, Javier Lamas Vigo, Ismael Ameneiros Rodriguez, Ricardo Veira Lorenzo, Juan Carlos Carral Couce and Luis Carral Couce    
The application of hydrodynamics to the definition of artificial reefs is of great interest since the positioning of the artificial reef modules on the sea floor alters the water velocity field, causing an appropriate circulation of nutrients and promoti... ver más

 
Clemens Zeile, Tobias Weber and Sebastian Sager    
Solving mixed-integer nonlinear programs (MINLPs) is hard from both a theoretical and practical perspective. Decomposing the nonlinear and the integer part is promising from a computational point of view. In general, however, no bounds on the objective v... ver más
Revista: Algorithms

 
Yonglian Han, Min Shao, Yunzhi Wu and Xiaoming Zhang    
The advancement of society and technology has promoted the development of modern agriculture. It has become a trend to replace traditional manpower with intelligent agricultural machinery that operates independently. As the core technology of intelligent... ver más
Revista: Information

 
Giuseppe Di Luca, Massimiliano Muccillo, Giovanni Giardiello, Alfredo Gimelli and Gabriele Di Blasio    
Internal combustion engine-driven railway vehicles play an important role in the sector even today, due to the incomplete electrification of railway routes. However, stringent COP26 environmental rules are driving manufacturers and the scientific communi... ver más
Revista: Applied Sciences

 
Stefano Silvestrini, Margherita Piccinin, Giovanni Zanotti, Andrea Brandonisio, Paolo Lunghi and Michèle Lavagna    
The exploration of celestial bodies such as the Moon, Mars, or even smaller ones such as comets and asteroids, is the next frontier of space exploration. One of the most interesting and attractive purposes from the scientific point of view in this field,... ver más
Revista: Aerospace