Resumen
Imaging-based predictors of HPV status could be used to non-invasively detect HPV positivity in cases in which biopsy is not feasible because of a hardly accessible tumor location, or when the HPV test results are conflicting. Radiomics signatures for HPV status would also help in OPSCC for an easier diagnosis in unknown primary head and neck tumors, contributing to re-ducing costs and invasiveness of the current gold-standard modality for disease diagnosis and staging. Lastly, it would be of interest to explore the role of image-based signatures for HPV status classification as prognostic biomarkers, in order to better identify distinct risk classes of OPSCC patients.